Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization
نویسندگان
چکیده
منابع مشابه
Immunotherapy for peanut allergy.
Peanut allergy is one of the commonest food hypersensitivities causing fatal or near-fatal reactions. There is, currently, no preventive treatment and the incidence of severe allergic reactions during peanut desensitisation has limited its clinical use. Anti-immunoglobulin E therapy has been shown to be effective in preventing peanut-induced reactions but it does not result in long-term toleran...
متن کاملSuccessful oral desensitization for systemic peanut allergy.
To the Editor: The present strategy of avoidance and epinephrine autoinjection for severe IgE-mediated food reactions is not always successful.1,2 This may be even truer for young children, who cannot read and have to depend on adults to administer the epinephrine. The following case report illustrates such a failure in a young child and describes a treatment that can be performed by an allergy...
متن کاملOral and sublingual immunotherapy for food allergy
OBJECTIVE Food allergies continue to be an increasingly common disorder, however, no treatment strategies are currently approved for the routine management of individuals with food allergies. Encouraging results from early open-label studies have sparked great interest in oral and sublingual immunotherapy, and thus several randomized controlled trials have recently been conducted to establish t...
متن کاملSublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial.
BACKGROUND We previously reported the initial results of the first multicenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunotherapy (SLIT), observing a favorable safety profile associated with modest clinical and immunologic effects in the first year. OBJECTIVE We sought to provide long-term (3-year) clinical and immunologic outcomes for our peanut S...
متن کاملSublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial.
BACKGROUND There are presently no available therapeutic options for patients with peanut allergy. OBJECTIVE We sought to investigate the safety, efficacy, and immunologic effects of peanut sublingual immunotherapy (SLIT). METHODS After a baseline oral food challenge (OFC) of up to 2 g of peanut powder (approximately 50% protein; median successfully consumed dose [SCD], 46 mg), 40 subjects, ...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2011
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2010.12.1083